Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
Identifieur interne : 000338 ( France/Analysis ); précédent : 000337; suivant : 000339Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
Auteurs : Guédé Noël Zirihi ; Philippe Grellier [France] ; Frédérick Guédé-Guina ; Bernard Bodo [France] ; Lengo Mambu [France]Source :
- Bioorganic and Medicinal Chemistry Letters [ 0960-894X ] ; 2005-05-16.
Abstract
Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.
Url:
DOI: 10.1016/j.bmcl.2005.03.021
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000145
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- to stream Main, to step Curation: 001E02
- to stream Main, to step Exploration: 001E02
- to stream France, to step Extraction: 000338
Links to Exploration step
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<front><div type="abstract" xml:lang="en"> <p>Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.</p>
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